Tea’s Potential Impact on Heart Health

Heart Health

Numerous epidemiological studies suggest that regularly drinking green, black or oolong tea may reduce risk factors for cardiovascular disease and lower rates of heart attacks, strokes and cardiovascular mortality. Tea is one of the most popular beverages globally, with black tea predominating in Western nations and green tea in Asian countries. Researchers have hypothesized that antioxidant compounds called polyphenols or flavonoids in tea may be bioactive ingredients conferring a heart health benefit.

Several large cohort studies found significantly lower rates of ischemic stroke, myocardial infarction or cardiovascular death among Japanese adults drinking 5 or more cups of green tea per day. Some European and American studies correlated black tea intake with reduced cardiovascular events and mortality as well, though a protective effect was not seen across all populations. Meta-analyses generally confirm that consumption of 3+ cups of green or black tea per day associates with 10-25% lower cardiovascular risk. Results remain mixed for oolong tea.

Proposed mechanisms behind tea’s cardiovascular benefits include lowering blood pressure, improving dyslipidemia, aiding weight/glucose control, exerting anti-inflammatory effects on arteries, enhancing endothelial function and slightly inhibiting platelet aggregation based on some trials. Yet individual human studies of each risk factor show inconsistent results. Overall there is modest evidence green and black tea mildly lowers LDL cholesterol, body mass index and new diabetes incidence over months or years – which could significantly impact population health long-term.

Regarding potential mechanisms, rodent studies clearly demonstrate bioactivity of tea compounds like epigallocatechin gallate (EGCG) in vivo – including antioxidant actions. Yet corresponding human trials fail to confirm tea polyphenols act as in vivo antioxidants once consumed in realistic dietary amounts that yield quite low bioavailability. This suggests other pathways are more relevant to vascular benefits observed epidemiologically with habitual tea intake.

Namely, short and long-term black or green tea consumption reliably improves endothelium-dependent vasodilation in patients with existing coronary disease as well as healthy adults. Benefits disappear shortly after isolated EGCG dosage ends, indicating regular exposure over time is key – not transient polyphenol blood spikes. Parallel experiments revealed tea flavanols enhance endothelial nitric oxide synthase activation on a sustained basis via specific cell signaling cascades (PI3K/AKT, p38 MAPK). Tea polyphenols also favorably regulate other proteins influencing nitric oxide production. Through such endothelial improvements, tea could aid vascular function and atheroprotection over decades.

Beyond endothelial bioactivity, tea compounds demonstrate anti-inflammatory, anti-platelet, and anti-proliferative effects in lab studies that may have protective implications long-term. Four-week tea intake moderately lowers in vivo platelet activation biomarkers in some trials, although ex vivo platelet aggregation was unaffected. While more research is warranted, lowering inflammatory factors, inhibiting vascular smooth muscle migration and reducing platelet adhesion could collectively impact atherogenesis or thrombotic complications over years.

No large-scale randomized controlled trials have directly tested whether long-term tea consumption prevents human cardiovascular morbidity or mortality. Carrying out such multi-year clinical trials poses extreme financial/logistical challenges and would require 5,000+ participants for statistical significance, precluding industry sponsorship. Regardless, some nutrition organizations suggest drinking unsweetened tea daily within heart-healthy dietary patterns for potential auxiliary cardiovascular benefits, given its safety plus consistent epidemiological and mechanistic clues. They emphasize pairing tea with lifestyle approaches clinically proven to reduce cardiovascular risk like healthy diets, exercise and smoking cessation rather than viewing tea as an alternative to medications.

In conclusion, integrating 3 to 5 servings of green, black or oolong tea could be reasonably expected to modestly influence cardiovascular risk over years as part of a comprehensive lifestyle regimen based on the preponderance of population data. However, individuals with diagnosed cardiovascular conditions should adhere to medical nutrition therapy and evidence-based care guidelines rather than independently changing their consumption of tea or other foods with unconfirmed effects. More rigorous clinical studies on specific tea preparations may eventually provide sufficient evidence to incorporate tea more definitively into dietary recommendations focused on heart health and disease prevention.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123419/pdf/nihms286623.pdf

Author